CD34 + Autologous Human Stem Cells in Treating Refractory Angina

CD34+ autologous human stem cells in treating refractory angina.

The article by Losordo et al1 in this issue of Circulation Research is an important addition to the relatively small body of literature in clinical cardiac stem cell therapy. Although the number of patients in the trial by Losordo et al is fairly small, only a handful of similarly sized trials have been published.2–4 In the recent past, the merit of performing clinical trials of cardiac cell th...

Intramyocardial, autologous CD34+ cell therapy for refractory angina.

RATIONALE A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can improve myocardial perfusion and function. OBJECTIVE Evaluate the safety and bioactivity of intramyocardial injections of autologous CD34+ cells in patients with refractory angina who have exhausted ...

Intracoronary autologous CD34+ stem cell therapy for intractable angina.

BACKGROUND/OBJECTIVES A large number of patients with coronary artery disease experience angina that is not suitable for revascularization and is refractory to conventional medical therapy. Laboratory and preclinical studies have provided evidence for the safety and potential efficacy of autologous CD34+ stem cell therapies as treatment for angina. Clinical studies investigating intramyocardial...

Harnessing the Potential of Human Autologous Stem Cells to Treat Refractory Angina.

R efractory angina pectoris is a debilitating clinical condition that has typically been used to describe a subset of patients with chest pain syndrome on maximally tolerated antianginal medical therapy, demonstrable myocardial ischemia, and no coronary revascularization options (1). A multitude of novel treatment options directed at patients with refractory angina, ranging from interventional ...

Clinical/Translational Research Intramyocardial, Autologous CD34 Cell Therapy for Refractory Angina